Our laboratory studies the biology of the NMDA receptor. We are interested in how NMDA receptor function contributes to the processes underlying learning and memory, at the molecular, cellular and network level. In addition, we are developing novel therapeutics for treating a range of neurological disorders in which NMDA receptor function is altered.
Blanke ML and VanDongen AMJ (2008), Constitutive activation of the N-Methyl-D-aspartate receptor via cleft-spanning disulfide bonds, J. Biol. Chem. 283: 21519 -29.
Bloomer WAC, VanDongen HMA and VanDongen AMJ (2008), Arc/Arg3.1 translation is controlled by convergent N-Methyl-D-aspartate and Gs-coupled receptor signaling pathways, J. Biol.
Chem. 283: 582-592.
Bloomer WAC, VanDongen HMA and VanDongen AMJ (2007), Activity-regulated cytoskeleton-associated protein Arc/Arg3.1 binds to spectrin and associates with nuclear promyelocytic leukemia (PML) bodies, Brain Res. 1153: 20-33.
Van de Ven TJ, VanDongen HMA and VanDongen AMJ (2005), The non-kinase phorbol ester receptor α1-chimaerin binds the NMDA receptor NR2A subunit and regulates dendritic spine density, J. Neurosci. 25: 9488-9496.
Grigston JC, VanDongen HMA, McNamara JO and VanDongen AMJ (2005), Translation of integral membrane proteins in distal dendrites of hippocampal neurons, Eur. J. Neurosci. 21: 1457-1468.
Kalbaugh TL, VanDongen HMA and VanDongen AMJ (2004), Ligand-binding residues integrate affinity and efficacy in the NMDA receptor, Mol. Pharmacol. 66: 209-219.
VanDongen AMJ (2004), K channel gating by an affinity-switching selectivity filter, Proc. Natl. Acad. Sci. USA 101: 3248-3252.
Jones KS, VanDongen, HMA and VanDongen, AMJ (2002), The NMDA receptor M3 segment is a conserved transduction element coupling ligand binding to channel opening, J. Neurosci. 22: 2044-2053.
Wood MW, VanDongen HMA and VanDongen AMJ (1996), The 5'-untranslated region of the N-methyl-D-aspartate receptor NR2A subunit controls efficiency of translation, J. Biol. Chem. 271(14): 8115-8120.
Wood MW VanDongen HMA and VanDongen AMJ (1995), Structural conservation of ion conduction pathways in K channels and glutamate receptors, Proc. Natl. Acad. Sci. USA 92: 4882-4886.